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Tetrahydropyrimidine derivatives inhibit binding of a Tat-like, arginine-containing peptide, to HIV TAR RNA in vitro

✍ Scribed by Aviva Lapidot; Edna Ben-Asher; Miriam Eisenstein


Book ID
115930886
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
583 KB
Volume
367
Category
Article
ISSN
0014-5793

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Interference of binding of Tat protein to TAR RNA in HIV-1-infected cells may be a useful therapeutic strategy for AIDS. An electrophoretic assay to screen potential low-molecular-weight (< 2 kDa) Tat antagonists has been established. A radiolabeled TAR RNA fragment (delta TAR) is retarded in mobili