A new proline-based spirotricyclic lactam is reported as an efficient type II 0 b-turn inducing peptidomimetic. After investigations of the reverse turn properties by computational techniques, the scaffold has been synthesized by a straightforward sequence relying on a key RCM reaction for the const
✦ LIBER ✦
Tetrahydroisoquinoline-Based Spirocyclic Lactam as a Type II′ β-Turn Inducing Peptide Mimetic
✍ Scribed by Lesma, Giordano; Landoni, Nicola; Pilati, Tullio; Sacchetti, Alessandro; Silvani, Alessandra
- Book ID
- 120188366
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 894 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3263
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