Tetraethyleneglycol diacrylate (TTEGDA)-crosslinked polystyrene resin as an efficient solid support for gel phase peptide synthesis
β Scribed by M. Renil; V. N. Rajasekharan Pillai
- Book ID
- 112907175
- Publisher
- Indian Academy of Sciences,Royal Society of Chemistry
- Year
- 1994
- Tongue
- English
- Weight
- 776 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0253-4134
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Three short peptides were synthesized on Merrifield resin (PS-DVB) and on polystyrene crosslinked with 1,6-hexanediol diacrylate resin (PS-HDODA) to compare their efficiencies in solid-phase peptide synthesis (SPPS). A 2% crosslinked polymeric system having almost equal capacity was used in both cas
A highly solvating copolymer was prepared in high yield by introducing a flexible crosslinker, 1,4-butanedioldimethacrylate, into the polystyrene matrix by a free radical aqueous suspension polymerization. A 2 mol% crosslinked resin showed rigidity and mechanical characteristics comparable to those