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Tetraethylammonium-insetisitive, Ca2+-activated whole-cell K+currents in rat submandibular acinar cells

✍ Scribed by Toru Ishikawa; Masataka Murakami

Book ID: 104746977
Publisher: Springer
Year: 1995
Tongue: English
Weight: 328 KB
Volume: 429
Category: Article
ISSN: 0031-6768
DOI: 10.1007/bf00373998

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✦ Synopsis

Using whole-cell patch-clamp techniques, we demonstrate, for the first time, that rat submandibular acinar cells contain a tetraethylammonium (TEA)-insensitive, Ca2+-activated K + conductance which is not attributable to large conductance, voltage-sensitive, Ca2+-dependent K+ channels (maxi-K+ channels). Taken together with our recent K + efflux and fluid secretion studies in intact rat submandibular gland, we postulate that the K § conductance reported here may be involved in the basolateral K + efflux pathway activated by cytosolic Ca2+ concentration during secretion by this gland.

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