The binding constants and the number of binding sites for the binding of 11 sulfonamide and seven penicillin derivatives to bovine serum albumin were determined using a fluorescence probe method. The results demonstrate that these drugs bind to hydrophobic sites on the serum albumin. The binding aff
Tetracycline binding to bovine serum albumin studied by fluorescent techniques
β Scribed by K. H. Joseph; H. W. Jun; Louis A. Luzzi
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 378 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
## Abstract The interaction of Ce^3+^ to bovine serum albumin (BSA) has been investigated mainly by fluorescence spectra, UVβvis absorption spectra, and circular dichroism (CD) under simulative physiological conditions. Fluorescence data revealed that the quenching mechanism of BSA by Ce^3+^ was a
following manner to fit the experimental findings : kobs. = kng20 fA-' + k'H,O fHA-(Eq. 8) Or it may be written in the kinetically equivalent: ## kobs. = OH-[OH-] faA--k OH-[OH-] ~H , A (Eq. 9) The specific catalytic rate constants for Eqs. 8 and 9 are given in Table 111 along with other pertine