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Competitive binding of two sulfas and penicillin G to bovine serum albumin using NMR techniques

✍ Scribed by H. Zia; R. H. Cox; L. A. Luzzi

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 386 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600600106

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✦ Synopsis

following manner to fit the experimental findings : kobs. = kng20 fA-' + k'H,O fHA-(Eq. 8)

Or it may be written in the kinetically equivalent:

kobs. = OH-[OH-] faA--k OH-[OH-] ~H , A (Eq. 9)

The specific catalytic rate constants for Eqs. 8 and 9 are given in Table 111 along with other pertinent data.

REFERENCES

📜 SIMILAR VOLUMES

Structure relationship for binding of su

Structure relationship for binding of sulfonamides and penicillins to bovine serum albumin by fluorescence probe technique

✍ Par-Lin Hsu; Joseph K. H. Ma; H. W. Jun; Louis A. Luzzi 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB

The binding constants and the number of binding sites for the binding of 11 sulfonamide and seven penicillin derivatives to bovine serum albumin were determined using a fluorescence probe method. The results demonstrate that these drugs bind to hydrophobic sites on the serum albumin. The binding aff