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Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells

✍ Scribed by Kristina K. Hansen; Mahmoud Saifeddine; Morley D. Hollenberg

Book ID: 108781438
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 236 KB
Volume: 112
Category: Article
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2004.01870.x

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## Abstract Proteinase‐activated receptor‐1 (PAR1), upon activation, exerts prostanoid‐dependent gastroprotection, and increases prostaglandin E~2~ (PGE~2~) release through cyclooxygenase‐2 (COX‐2) upregulation in rat gastric mucosal epithelial RGM1 cells. However, there is a big time lag between t