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The role of protease-activated receptors PAR-1 and PAR-2 in the repair of 16HBE 14o− epithelial cell monolayers in vitro

✍ Scribed by D. Ewen; S.L. Clarke; J.R. Smith; C. Berger; G. Salmon; M. Trevethick; J.K. Shute

Book ID: 108688690
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 440 KB
Volume: 40
Category: Article
ISSN: 0954-7894
DOI: 10.1111/j.1365-2222.2010.03453.x

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## Abstract Proteinase‐activated receptor‐1 (PAR1), upon activation, exerts prostanoid‐dependent gastroprotection, and increases prostaglandin E~2~ (PGE~2~) release through cyclooxygenase‐2 (COX‐2) upregulation in rat gastric mucosal epithelial RGM1 cells. However, there is a big time lag between t