Tests of the helix dipole model for stabilization of α-helices
✍ Scribed by Shoemaker, Kevin R.; Kim, Peter S.; York, Eunice J.; Stewart, John M.; Baldwin, Robert L.
- Book ID
- 109749007
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 508 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/326563a0
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📜 SIMILAR VOLUMES
The electrostatic interactions between a-helix dipoles in the crystals of an uncharged helical undecapeptide have been studied in detail. The electrostatic interaction energy between one helix dipole and its 26 nearest neighbors is approximately -23 kcal mol-'. A very similar result is obtained when
## Abstract The aim of the present investigation is to determine the effect of α‐helical propensity and sidechain hydrophobicity on the stability of amphipathic α‐helices. Accordingly, a series of 18‐residue amphipathic α‐helical peptides has been synthesized as a model system where all 20 amino ac