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Testing and Estimating Gene–Environment Interactions in Family-Based Association Studies

✍ Scribed by Stijn Vansteelandt; Dawn L. DeMeo; Jessica Lasky-Su; Jordan W. Smoller; Amy J. Murphy; Matt McQueen; Kady Schneiter; Juan C. Celedon; Scott T. Weiss; Edwin K. Silverman; Christoph Lange

Book ID: 109223844
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 191 KB
Volume: 64
Category: Article
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2007.00925.x

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## Abstract Family‐based case‐control studies are popularly used to study the effect of genes and gene‐environment interactions in the etiology of rare complex diseases. We consider methods for the analysis of such studies under the assumption that genetic susceptibility (__G__) and environmental e