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tert-Butyl Ethers: Renaissance of an Alcohol Protecting Group. Facile Cleavage with Cerium(III) Chloride/Sodium Iodide

✍ Scribed by Giuseppe Bartoli; Marcella Bosco; Armando Carlone; Manuela Locatelli; Enrico Marcantoni; Paolo Melchiorre; Letizia Sambri

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 107 KB
Volume: 348
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200505469

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✦ Synopsis

Abstract

The tert‐butoxy derivative is one of the most underused alcohol protecting groups. After having developed an easy and useful protocol for its introduction, we offer here a simple procedure for its removal by treatment with anhydrous CeCl~3~ and NaI in CH~3~CN. The procedure led to the successful cleavage of aliphatic and aromatic tert‐butyl ethers and was compatible with various other functionalities and protecting groups present in the molecule.

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tert-Butyl Ethers: Renaissance of an Alc

tert-Butyl Ethers: Renaissance of an Alcohol Protecting Group. Facile Cleavage with Cerium(III) Chloride/Sodium Iodide.

✍ Giuseppe Bartoli; Marcella Bosco; Armando Carlone; Manuela Locatelli; Enrico Mar 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 32 KB

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