Terphenylquinone Inhibitors of the Src Protein Tyrosine Kinase from Stilbella sp.
β Scribed by Puder, Carsten; Wagner, Klaus; Vettermann, Regine; Hauptmann, Rudolf; Potterat, Olivier
- Book ID
- 127190531
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0163-3864
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π SIMILAR VOLUMES
Conformational searches on three closely related pp60 c-src protein tyrosine kinase inhibitors of varying potencies were performed to determine a structural basis for their activity. The first was a linear peptide (PDNEYAFFQf), the second its 10-membered cyclic analogue, and the third a cyclic analo
## ABSTRACT The peripheral nonβreceptor tyrosine kinase oncoprotein, vβSrc, has pleiotropic effects. It is a mitogen for quiescent cells, substituting for both competence and progression factorβmediated signals but it also induces cellular morphological transformation. We are dissecting the activit