## ABSTRACT The peripheral non‐receptor tyrosine kinase oncoprotein, v‐Src, has pleiotropic effects. It is a mitogen for quiescent cells, substituting for both competence and progression factor‐mediated signals but it also induces cellular morphological transformation. We are dissecting the activit
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases
✍ Scribed by Yuh-Ping Chong; Kim Kui Ia; Terrence D. Mulhern; Heung-Chin Cheng
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 510 KB
- Volume
- 1754
- Category
- Article
- ISSN
- 1570-9639
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## Abstract PTP–PEST is involved in the regulation of sealing ring formation in osteoclasts. In this article, we have shown a regulatory role for PTP–PEST on dephosphorylation of c‐Src at Y527 and phosphorylation at Y418 in the catalytic site. Activation of Src in osteoclasts by over‐expression of