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Teratogenicity of N-(4-hydroxyphenyl) -all-trans-retinamide in rats and rabbits

✍ Scribed by Dr. Michael F. Kenel; John H. Krayer; Eileen A. Merz; J. Fred Pritchard

Book ID
112213344
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
691 KB
Volume
8
Category
Article
ISSN
0270-3211

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## Abstract We studied the effects of 13‐cis‐retinoic acid (13cRA) and 4‐hydroxyphenyl‐all‐trans‐retinamide (4HPR) on the proliferation of clonogenic human tumor colony‐forming units (TCFU) from patient biopsies in soft agar. Continuous exposure (5 Γ— 10^βˆ’6^M) to 13cRA and 4HPR reduced colony format