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Subacute toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide, N-2-hydroxyethyl retinamide, and N-4-hydroxyphenyl retinamide

✍ Scribed by Brahma P. Sani; Robert G. Meeks


Book ID
113206039
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
695 KB
Volume
70
Category
Article
ISSN
0041-008X

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Effect of 13-cis-retinoic acid and 4-hyd
✍ Frank L. Meyskens Jr.; David S. Alberts; Sydney E. Salmon πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 French βš– 498 KB πŸ‘ 1 views

## Abstract We studied the effects of 13‐cis‐retinoic acid (13cRA) and 4‐hydroxyphenyl‐all‐trans‐retinamide (4HPR) on the proliferation of clonogenic human tumor colony‐forming units (TCFU) from patient biopsies in soft agar. Continuous exposure (5 Γ— 10^βˆ’6^M) to 13cRA and 4HPR reduced colony format