Tenascin-C in astrocytic tumors
β Scribed by Giuseppe Viale; Alessandra Dorcaratto; Patrizia Castellani; Laciano Zardi
- Book ID
- 117260734
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 39 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0090-3019
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## Abstract Astrocytic scar formation occurs subsequent to brain and spinal cord injury and impedes repair. The exact mechanisms of scar formation have yet to be elucidated but it is known that astrocytes within the scar have a different antigenic phenotype from normal or reactive astrocytes. Astro
In normal adult tissue tenascin-C (TN-C) is usually expressed at low levels. However, it is strongly induced in many tumors as well as in other pathological conditions often associated with inflammation. To evaluate the diagnostic significance of TN-C,
Tenascin-C is an extracellular matrix glycoprotein with trophic and repulsive properties on neuronal cells, involved in migratory processes of immature neurons. Previous reports demonstrated that this molecule is produced and secreted by astrocytes, in vitro after activation by bFGF or in vivo after