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Expression of tenascin-C in astrocytic tumors: its relevance to proliferation and angiogenesis

✍ Scribed by Choong Hyun Kim; Koang Hum Bak; Young Soo Kim; Jae Min Kim; Yong Ko; Suck Jun Oh; Kwang Mung Kim; Eun Kyung Hong

Book ID
117260288
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
283 KB
Volume
54
Category
Article
ISSN
0090-3019

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## Background: Tenascin-c (tn-c), a large extracellular matrix (ecm) glycoprotein with a molecular weight of 180-250 kilodaltons, is present in several normal adult tissues. tn-c is up-regulated during embryogenesis, in wound healing, and in tumor tissues. glioblastoma multiforme (gbm) is the most

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Tenascin-C regulates angiogenesis in tumor through the regulation of vascular endothelial growth factor expression
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## Abstract In order to verify whether tenascin‐C (TN‐C) is involved in angiogenesis as an extracellular signal molecule during tumorigenesis, cancerous cell transplantation experiments and coculture experiments were carried out, focusing on the regulation of vascular endothelial growth factor (VEG