Temporary serine protection in solid phase synthesis of LH-RH analogs
โ Scribed by ARZENO, H.B. ;BINGENHEIMER, W. ;BLANCHETTE, R. ;MORGANS, D.J. ;ROBINSON, J.
- Book ID
- 115099514
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 446 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0367-8377
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๐ SIMILAR VOLUMES
The compound A~GlcNACgl-NH-Fmoc (3) was eynthesixed and transformed into the &gluwsyl amine (1) which was subsequently acylated with Fmoc-Asp(CI)-Gpfp (5) prepared from the readily available Fmoc-Asp@-tBu)-G-pfp (4). The resulting Fmoc-Asn(A~GlcNAcfil-N-)-O-Pfp (6) was used as a buildiug block in th
A new hydroxy-protecting group for Ser, cyclohexyl, has been developed, and its application to the solid-phase peptide synthesis has been demonstrated successfully in combination with Nยฐt-Boc protection and the Merrifield resin support.