✦ LIBER ✦

Temporally regulated expression of insulin and insulin-like growth factors and their receptors in early mammalian development

✍ Scribed by Susan Heyner; Robert M. Smith; Gilbert A. Schultz

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 706 KB
Volume: 11
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950110604

No coin nor oath required. For personal study only.

✦ Synopsis

Recent studies of early development in a number of invertebrate and vertebrate species have suggested that growth factors and their receptors may play important roles in diferentiation as well as cell prolijeration. In the mouse embryo, the expression of the receptors for insulin and insulin-like growth factors I and 11 (IGF-I and -I0 are temporally regulated. The ontogeny of receptor and ligand expression within the insulin and IGF genejumily suggests that the very earliest stages of mammalian embryogenesis may he subject to regulation bv autocrine and paracrine factors ,from maternal and embryonic sources.

📜 SIMILAR VOLUMES

Expression of insulin-like growth factor

Expression of insulin-like growth factor II and receptors for insulin-like growth factor II, insulin-like growth factor I and insulin in isolated and cultured rat hepatocytes

✍ Eugenia Lamas; Frédérique Zindy; Danielle Seurin; Christiane Guguen-Guillouzo; C 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 714 KB

Insulin-like growth factor I1 is believed to play an important role in fetal growth and development. The insulin-like growth factor I1 gene expression is tissue specific and developmentally regulated. We have previously shown an enhanced level of insulin-like growth factor I1 messenger RNA and prote

Insulin-like growth factor family in mal

Insulin-like growth factor family in malignant haemangiopericytomas: the expression and role of insulin-like growth factor I receptor

✍ Paveli?, Kre?imir; Paveli?, Zlatko P.; Cabrijan, Tomislav; Karner, Ivan; Samar?i 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 2 views

Haemangiopericytoma is a rare soft tissue tumour originating from the contractile pericapillary cells. Relatively little is known about its molecular pathogenesis. To address this issue, the insulin-like growth factor family (IGFs) was analysed in 19 tumours collected from a human tumour bank networ

Down-regulation of insulin-like growth f

Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer

✍ Bernd Schnarr; Kathrin Strunz; Jürgen Ohsam; Axel Benner; Jürgen Wacker; Doris M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 610 KB

Role of insulin-like growth factor-I in

Role of insulin-like growth factor-I in regulating estrogen receptor-α gene expression

✍ Adriana Stoica; Miguel Saceda; Amina Fakhro; Michael Joyner; Mary Beth Martin 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 1 views

The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o

Biology of insulin-like growth factors i

Biology of insulin-like growth factors in development

✍ Joëlle Dupont; Martin Holzenberger 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 329 KB 👁 1 views

Estradiol and progesterone regulate the

Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats

✍ Cardona-G�mez, G. P. ;Chowen, J. A. ;Garcia-Segura, L. M. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

## Gonadal hormones interact with in- sulin-like growth factor-I (IGF-I) to regulate synaptic plasticity during the estrous cycle in the rat mediobasal hypothalamus. It has been proposed that tanycytes, specialized glial cells lining the ventral region of the third ventricle, may regulate the avail