Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus
β Scribed by David E. Fisher; Westley H. Reeves; Rosanne Wisniewolski; Robert G. Lahita; Nicholas Chiorazzi
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 887 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0004-3591
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## Objective. The implied role of retroviruses in the pathogenesis of murine systemic lupus erythematosus (SLE) led us to study antiretroviral antibodies in a population-based SLE cohort. Methods. Immunoassays using whole virus and synthetic peptides were performed on sera from 72 patients with SL
## Abstract Thirty patients with systemic lupus erythematosus (SLE( were studied over a 2.5βyear period. The group was divided into 14 patients with antibodies to Sm and a control group which failed to exhibit antibodies to Sm over the study period. The titer of antibodies to Sm fluctuated in all 1
## Abstract Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4Β°C. IgG antibodies were infrequent