๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Temperature-Dependent Enhancement of Proteolysis in C2C12 Myotubes in Association with the Activation of 26S Proteasome

โœ Scribed by Shunji Morita; Toshimasa Tsujinaka; Masahiko Yano; Chikara Ebisui; Takashi Morimoto; Junya Fujita; Atsuhiro Ogawa; Masaaki Taniguchi; Hitoshi Shiozaki; Morito Monden


Book ID
115579396
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
264 KB
Volume
228
Category
Article
ISSN
0006-291X

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## Abstract Two muscleโ€specific ubiquitin ligases (UL), muscle atrophy F box (MAFbx) and muscle RING finger 1 (MuRF1), are crucial for myofibrillar protein breakdown. The insulin like growth factorโ€1 (IGFโ€1) pathway inhibits muscle UL expression through Aktโ€mediated inhibition of FoxO transcription