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Temperature and pH sensitivity of the partition coefficient as related to the blood-brain barrier to drugs

✍ Scribed by Joyce J. Kaufman; Walter S. Koski; Donald W. Benson

Book ID: 117100442
Publisher: Elsevier Science
Year: 1977
Tongue: English
Weight: 215 KB
Volume: 25
Category: Article
ISSN: 0014-4835
DOI: 10.1016/s0014-4835(77)80018-3

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## Abstract We describe the use of relative proton density imaging to obtain spatially resolved measurements of the brain:blood partition coefficient for water. Values of relative proton density and apparent‐T1 were calculated by performing a multidimensional nonlinear least squares fit of progress