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Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone

โœ Scribed by Gebre-Medhin, S.; Broberg, K.; Jonson, T.; Gorunova, L.; Vult von Steyern, F.; Brosjö, O.; Jin, Y.; Gisselsson, D.; Panagopoulos, I.; Mandahl, N.; Mertens, F.

Book ID
121303945
Publisher
S. Karger AG
Year
2009
Tongue
French
Weight
172 KB
Volume
124
Category
Article
ISSN
1424-8581

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Cytogenetic analysis of 101 giant cell t
Cytogenetic analysis of 101 giant cell tumors of bone: Nonrandom patterns of telomeric associations and other structural aberrations
โœ Ludmila Gorunova; Fredrik Vult von Steyern; Clelia Tiziana Storlazzi; Bodil Bjer ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 321 KB ๐Ÿ‘ 1 views

## Abstract Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor with metastatic potential. We performed cytogenetic analysis on 101 GCTB from 92 patients. Karyotypes were obtained from 95 tumors, 47 of which had clonal aberrations. The majority of the cytogenetically abnormal G