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Telomeres and telomerase in hematologic neoplasia

✍ Scribed by Ohyashiki, Junko H; Sashida, Goro; Tauchi, Tetsuzo; Ohyashiki, Kazuma

Book ID: 110066297
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 218 KB
Volume: 21
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1205075

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Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de now by telomerase, an unusua