Telomere maintenance in clinical medicine
β Scribed by Gary A. Ulaner
- Book ID
- 116210207
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 179 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1555-7162
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Despite the recent discovery of interchromosomal telomere length variation, a role for heterogeneity in telomere maintenance has yet to be established. This study investigated the significance of telomere length variation between chromosomes with respect to the associatio
## Abstract Telomeres are composed of specialized chromatin that includes DNA repair/recombination proteins, telomere DNAβbinding proteins and a number of three dimensional nucleic acid structures including Gβquartets and Dβloops. A number of studies suggest that the BLM and WRN recQβlike helicases
Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates). In most normal human cells, telomeres shorten with each cell division, and it is proposed that this limits the number of times these cells can replicate. Telomeres may be mainta