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Recombination in telomere-length maintenance

โœ Scribed by Alyson Kass-Eisler; Carol W Greider


Book ID
114326661
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
154 KB
Volume
25
Category
Article
ISSN
0968-0004

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Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates). In most normal human cells, telomeres shorten with each cell division, and it is proposed that this limits the number of times these cells can replicate. Telomeres may be mainta

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## Abstract ## BACKGROUND Despite the recent discovery of interchromosomal telomere length variation, a role for heterogeneity in telomere maintenance has yet to be established. This study investigated the significance of telomere length variation between chromosomes with respect to the associatio