Telomere Length Variation and Telomerase Activity Expression in Patients with Congenital and Acquired Aplastic Anemia
β Scribed by Polychronopoulou, Sophia; Koutroumba, Paraskevi
- Book ID
- 120222056
- Publisher
- S. Karger AG
- Year
- 2004
- Tongue
- English
- Weight
- 122 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0001-5792
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## BACKGROUND. Telomeres shorten with successive cell divisions in normal somatic cells. Telomerase is a ribonucleoprotein enzyme associated with cellular proliferation and plays an important role in maintaining the stability of chromosomes and the length of DNA telomeres. Telomerase activity has
## Abstract In a previous study, we showed that telomerase activity (TA) and human telomerase reverse transcriptase (hTERT) mRNA expression were undetectable in benign mesenchymal lesions and lowβgrade soft tissue sarcomas (STSs), but detectable in about 50% of intermediateβ/highβgrade STSs. We won