Telomerase Activity Increased and Telomere Length Shortened in Peripheral Blood Cells from Patients with Immune Thrombocytopenia
โ Scribed by Qi, Aiping; Zhou, Hu; Zhou, Zeping; Huang, Xin; Ma, Li; Wang, Hongmei; Yang, Yanhui; Zhang, Donglei; Li, Huyuan; Ren, Ruimin; Yang, Renchi
- Book ID
- 120221556
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 337 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0271-9142
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Recently, shortened telomere length and increased telomerase activity have been demonstrated in various human cancers. In the study reported here, we ascertained whether gene changes are characteristic of pancreatic cancers. Hamster duct carcinomas and cell lines were investigated by Southern blot a
## BACKGROUND. Telomeres shorten with successive cell divisions in normal somatic cells. Telomerase is a ribonucleoprotein enzyme associated with cellular proliferation and plays an important role in maintaining the stability of chromosomes and the length of DNA telomeres. Telomerase activity has