## BACKGROUND. Telomeres shorten with successive cell divisions in normal somatic cells. Telomerase is a ribonucleoprotein enzyme associated with cellular proliferation and plays an important role in maintaining the stability of chromosomes and the length of DNA telomeres. Telomerase activity has
β¦ LIBER β¦
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals
β Scribed by Hiroshi Iwama; K. Ohyashiki; Junko H. Ohyashiki; Shigifumi Hayashi; Naoyuki Yahata; Keiko Ando; Keisuke Toyama; Akinori Hoshika; Masaru Takasaki; Mayumi Mori; Jerry W. Shay
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 112 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0340-6717
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## Abstract ## BACKGROUND. A decrease in the age at cancer onset and increase in cancer incidence in successive generations in LiβFraumeni syndrome (LFS) families with germline __TP53__ mutations have been previously described. In the current study a possible relation was analyzed between telomere