Telomere instability detected in sporadic colon cancers, some showing mutations in a mismatch repair gene
β Scribed by Pickett, Hilda Amelia; Baird, Duncan Martin; Hoff-Olsen, Per; Meling, Gunn Iren; Rognum, Torleiv Ole; Shaw, Jacqui; West, Kevin Paul; Royle, Nicola Jane
- Book ID
- 110068553
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 238 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes. Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers. A defect in DNA mismatch repair results in an RER (replication e
Germline alterations in human DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Mutation analysis of the genes reveals carriers with a high risk of colorectal cancer, who will benefit from surveillance. We wanted to find the best predictive parameter of