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Telomere-driven replicative senescence is a stress response

โœ Scribed by Zglinicki, Thomas von; Petrie, Joanne; Kirkwood, Thomas B.L.

Book ID
109901972
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
264 KB
Volume
21
Category
Article
ISSN
1087-0156

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Human diploid "broblast cells can divide for only a limited number of times in vitro, a phenomenon known as replicative senescence or the Hay#ick limit. Variability in doubling potential is observed within a clone of cells, and between two sister cells arising from a single mitotic division. This st