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Telomere association of chromosomes induced by aphidicolin in a normal individual

✍ Scribed by C. Fuster; R. Miró; L. Barrios; J. Egozcue

Publisher
Springer
Year
1990
Tongue
English
Weight
331 KB
Volume
84
Category
Article
ISSN
0340-6717

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✦ Synopsis

Telomere association of chromosomes of a phenotypically and mentally normal individual was detected in 11.7% of metaphases cultured in RPMI-1640 with aphidicolin. No preferential involvement of any chromosome pair was detected. In two other individuals the frequency of telomere associations was much lower (1.9% and 0.7% respectively) under the same culture conditions. In the first individual the high number of telomere associations in cultures with aphidicolin along with the presence of telomere association (2.4%) in cultures with F.10 medium alone could reflect a constitutional telomere anomaly that is more often expressed in the presence of aphidicolin.

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