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Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p– syndrome

✍ Scribed by Hong-Yan Du; Rachel Idol; Sara Robledo; Jennifer Ivanovich; Ping An; Arturo Londono-Vallejo; David B. Wilson; Philip J. Mason; Monica Bessler


Book ID
111199418
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
242 KB
Volume
6
Category
Article
ISSN
1474-9718

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Telomeres play an important role in maintaining chromosomal stability and are often shortened in transformed cells. p53 is the most commonly mutated gene in cancers and its status is thought to reflect the level of genomic stability. We measured telomeric length by Southern blot analysis in cells fr