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Telomerase inhibitors and the role of telomerase in maintaining telomeres and chromosome stability

โœ Scribed by Brad Windle; Ira Maine; Claudia Flores; Diane Adrian; Shih-Fong Chen


Book ID
113253811
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
159 KB
Volume
84
Category
Article
ISSN
0165-4608

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Telomere shortening limits the proliferative capacity of primary human cells and restrains the regenerative capacity of organ systems during chronic diseases and aging. Telomere shortening apparently has a dual role in tumor development and progression. On the one hand, it induces chromosomal instab