Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
β Scribed by Shammas, M A; Koley, H; Bertheau, R C; Neri, P; Fulciniti, M; Tassone, P; Blotta, S; Protopopov, A; Mitsiades, C; Batchu, R B
- Book ID
- 109886824
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 385 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact
## Abstract We have recently described MAZ51, an indolinone that blocks the ligandβinduced autophosphorylation of VEGFRβ3, a receptor tyrosine kinase that plays a central role in the regulation of lymphangiogenesis. Here we show that MAZ51 is able to block the proliferation of VEGFRβ3βexpressing hu