Telomerase activity in oral and maxillofacial tumors
โ Scribed by J. Liao; T. Mitsuyasu; K. Yamane; M. Ohishi
- Book ID
- 114393647
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 239 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1368-8375
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## Background: Shortening of telomeres occurs with each cell division and eventually results in cell death. the activity of telomerase, an enzyme that catalyzes telomere elongation, has been detected in germ cell lines and cancer cells, and has been detected in immortal cell lines but not in normal
## BACKGROUND. Telomerase activity has been observed in 80 -90% of carcinomas derived from various organs. However, to the authors' knowledge this report is the first assessment of telomerase activity in gastrointestinal stromal tumors (GISTs). ## METHODS. Telomerase activity was analyzed by th