TEL-AML1 fusion transcript designates a favorable outcome with an intensified protocol in childhood acute lymphoblastic leukemia
β Scribed by Avigad, S; Kuperstein, G; Zilberstein, J; Liberzon, E; Stark, B; Gelernter, I; Kodman, Y; Luria, D; Ash, S; Stein, J
- Book ID
- 110054111
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 106 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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π SIMILAR VOLUMES
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence
## Abstract ## Background Genetic aberrations provide prognostic information in childhood ALL. The proportion of patients with detectable aberrations can be increased by combining Gβbanding with comparative genomic hybridization (CGH). ## Procedure We studied 79 children with ALL by CGH and Gβba