## Abstract Chronic constipation is the most frequent symptom of autonomic system involvement in Parkinson's disease (PD). Quite often the symptom is severe and impairs patients' quality of life. The objective of this study is to determine the efficacy and safety of an isosmotic macrogol solution f
Tegaserod (Zelnorm) for the treatment of constipation in Parkinson's disease
β Scribed by Kelly L. Sullivan; Joseph F. Staffetti; Robert A. Hauser; Peter B. Dunne; Theresa A. Zesiewicz
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 45 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
We performed a doubleβblind randomized placeboβcontrolled pilot study to determine the efficacy of tegaserod (Zelnorm) in treating constipation in 15 patients with Parkinson's disease (PD). There was a trend for improvement in the Subject's Global Assessment (SGA) of satisfaction with bowel habits (NS) and the total SGA (including abdominal discomfort, bothersome constipation, and satisfaction; NS). Β© 2005 Movement Disorder Society
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