Viral vectors in the treatment of Parkinson's disease

✍ Scribed by David S. Latchman; Robert S. Coffin

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 88 KB
• Volume: 15
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/1531-8257(200001)15:1<9::aid-mds1004>3.0.co;2-5

✦ Synopsis

s disease is an obvious target for the development of gene therapy procedures which could involve both the delivery of the gene encoding tyrosine hydroxylase to boost dopamine production or the delivery of genes encoding neurotrophic factors such as GDNF to promote the survival of dopaminergic neurons. A variety of different viral and non-viral methods for achieving such gene delivery are described together with the particular advantages of herpes simplex virusbased vectors which have the potential to deliver multiple therapeutic genes in a single virus vector.