𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Teaching the role of mitochondrial transport in energy metabolism

✍ Scribed by Salvatore Passarella; Anna Atlante

Publisher
The American Society for Biochemistry and Molecular Biology
Year
2007
Tongue
English
Weight
748 KB
Volume
35
Category
Article
ISSN
1470-8175

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Studies from our laboratories over recent years have uncovered the existence, and established the properties of a variety of mitochondrial transporters. The properties of these transporters throw light on a variety of biochemical phenomena that were previously poorly understood. In particular the role of mitochondrial transport in energy metabolism has been investigated under a variety of physio‐pathological conditions. Consistently we describe the procedure to investigate mitochondrial traffic in isolated mitochondria as a model system for students to learn. Here we report some observations that contribute to novel knowledge of the role of mitochondria in glycolysis, urea and purine nucleotide cycle, and nitrogen metabolism with particular reference to the malate/oxaloacetate shuttle and fumarate, glutamine, and lactate metabolism.

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