TCR Vα14+ natural killer T cells function as effector T cells in mice with collagen-induced arthritis
✍ Scribed by Y. Ohnishi; A. Tsutsumi; D. Goto; S. Itoh; I. Matsumoto; M. Taniguchi; T. Sumida
- Book ID
- 110090435
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 265 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0009-9104
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## Abstract ## Objective OCH, a synthetic analog of α‐galactosylceramide with a truncated sphingosine chain, stimulates natural killer T (NKT) cells to produce predominantly Th2 cytokines. Thus, OCH may be a potential agent for the treatment of Th1‐mediated autoimmune diseases. This study was desi
## Abstract H‐I and H‐II high antibody‐responder Biozzi mice, which express the H‐2^q^ permissive haplotype, were shown to be sensitive and refractory to collagen‐induced arthritis, respectively. To assess a possible role of T cell receptor (TcR) V~β~ gene deletion or polymorphism in the resistance