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TCR usage in human and experimental demyelinating disease

✍ Scribed by David A. Hafler; Mark G. Saadeh; Vijay K. Kuchroo; Edgar Milford; Lawrence Steinman


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
517 KB
Volume
17
Category
Article
ISSN
0167-5699

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## Experimental autoimmune encephalomyelitis (EAE) has served as a model for human demyelinating diseases, including multiple sclerosis. EAE is mediated by CD4 Ψ‰ T lymphocytes of the TH1 subset. These T cells produce inflammatory cytokines and chemokines that are associated with pathogenicity. The