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Concordance and contradiction concerning cytokines and chemokines in experimental demyelinating disease

✍ Scribed by R.B. Smeltz; R.H. Swanborg

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
51 KB
Volume
51
Category
Article
ISSN
0360-4012

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✦ Synopsis

Experimental autoimmune encephalomyelitis (EAE)

has served as a model for human demyelinating diseases, including multiple sclerosis. EAE is mediated by CD4 ؉ T lymphocytes of the TH1 subset. These T cells produce inflammatory cytokines and chemokines that are associated with pathogenicity. The disease is downregulated by other T cells, presumably of the TH2 subset that secrete a different pattern of cytokines which modulate the activity of the pathogenic TH1 cells. Ongoing studies should provide insight into how the interactions of T-cell subsets impact on the pathogenesis of autoimmune demyelinating diseases.

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