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TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi

✍ Scribed by Silvia H. Fernández Villamil; Rodrigo Baltanás; Guillermo D. Alonso; Salomé C. Vilchez Larrea; Héctor N. Torres; Mirtha M. Flawiá


Book ID
113654704
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
947 KB
Volume
38
Category
Article
ISSN
0020-7519

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Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD ؉ covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either double-or single-strand DNA breaks without any appar