## Abstract We have examined highly purified osteoclasts that were generated in vitro from murine co‐culture of marrow precursors with stromal support cells and have found evidence of activation of the MEK/ERK and AKT/NFκB survival pathways. Many mature marrow‐derived osteoclasts survived for at le
✦ LIBER ✦
TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-κB signaling pathway
✍ Scribed by Rong, Rong; He, Qin; Liu, Yusen; Sheikh, M Saeed; Huang, Ying
- Book ID
- 110066370
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 356 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Background Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signaling include direct regulators of cell cycle progress