Co-activation of the phosphatidylinositol-3-kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons

Characterization of the activation of gl

Characterization of the activation of glutaminase induced by N-methyl-D-aspartate and potassium in cerebellar granule cells

✍ S. Alavez; L. Gutiérrez-Kobeh; J. Morán 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 884 KB

Chronic stimulation of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or KCI induces a specific activation of the enzymes directly involved in glutamate neurotransmitter synthesis. Phosphate-activated glutaminase (PAG) activity is enhanced in cultured granule neurons incubated with 150 pM