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Tay-Sachs disease and normal cerebellar cells in culture: Elevated levels of lysosomal enzymes in Tay-Sachs disease cells

✍ Scribed by Dr. Linda M. Hoffman; Steven E. Brooks; Larry Schneck

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
342 KB
Volume
8
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Tay‐Sachs disease and normal fetal cerebellar cells were maintained in culture for up to four weeks. Elevated levels of the lysosomal enzymes hexosaminidase B, β‐galactosidase, and acid phosphatase were observed in the Tay‐Sachs cells in long term cultures although elevated lysosomal enzyme levels were not observed in the normal cultures. Similarly, elevated lysosomal enzyme activities were observed in Tay‐Sachs cultures which had been treated with Concanavalin A.

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