Structure-activity relationships of taxo
Structure-activity relationships of taxolยฎ: synthesis and biological evaluation of C2 taxol analogs
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Shu-Hui Chen; Vittorio Farina; Jian-Mei Wei; Bryon Long; Craig Fairchild; Stephe
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Article
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1994
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Elsevier Science
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English
โ 278 KB
Red-Al was used to selectively remove the C2 benroate of 7,13-bisTES baccatin (8). Derivatization of the resulting Cz hydroxy compound provided the corresponding p-nitrophenyl ~arbamate, the p-methoxy and p-nitrobenzoates, and cyclohexyl ester. Attachment of the tax01 side chain to the above four an