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Taxol structure-activity relationships: synthesis and biological evaluation of 10-deoxytaxol

โœ Scribed by Chen, Shu Hui; Fairchild, Craig; Mamber, Stephen W.; Farina, Vittorio


Book ID
126939721
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
169 KB
Volume
58
Category
Article
ISSN
0022-3263

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Red-Al was used to selectively remove the C2 benroate of 7,13-bisTES baccatin (8). Derivatization of the resulting Cz hydroxy compound provided the corresponding p-nitrophenyl ~arbamate, the p-methoxy and p-nitrobenzoates, and cyclohexyl ester. Attachment of the tax01 side chain to the above four an