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Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere

โœ Scribed by Ojima, Iwao; Fenoglio, Ivana; Park, Young Hoon; Sun, Chung Ming; Appendino, Giovanni; Bernacki, Ralph J.; Pera, Paula


Book ID
120508767
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
579 KB
Volume
59
Category
Article
ISSN
0022-3263

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Red-Al was used to selectively remove the C2 benroate of 7,13-bisTES baccatin (8). Derivatization of the resulting Cz hydroxy compound provided the corresponding p-nitrophenyl ~arbamate, the p-methoxy and p-nitrobenzoates, and cyclohexyl ester. Attachment of the tax01 side chain to the above four an