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Taurine biosynthesis in frog retina: Effects of light and dark adaptations

โœ Scribed by Chihiro Nishimura; Shuji Ida; Kinya Kuriyama

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
529 KB
Volume
9
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

The retinal uptake and metabolism of cysteine, a precursor for taurine biosynthesis, were analysed using the bull frog. The [I4C] cysteine uptake into isolated retina had some specific properties: It was rather temperature independent, required Na ions, was inhibited by ouabain but not by dinitrophenol, and exhibited saturation kinetics composed of two components. When retinal homogenate was incubated with 12-30 p M of L-[U-14C]cysteine, the accumulation of labeled alanine, cysteine sulfinic acid (CSA), cysteic acid (CA), hypotaurine, and taurine was detected. The metabolic conversions of [I4C] cysteine to labeled alanine, hypotaurine, and taurine were linear over 90 minutes. Prolonged light adaptation (3 weeks) induced a significant reduction in the formation of labeled CA, CSA, hypotaurine, and taurine from [I4C] cysteine. On the other hand, it was found that in dark-adapted retinae, the formation of labeled taurine from [ 14C] cysteine increased significantly in spite of the reduction in the formation of labeled CA. These results indicate that biosynthetic pathways exist for taurine from cysteine in frog retina, and that these metabolic pathways are involved in the regulation of retinal taurine content under continuous visual adaptation.

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